Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan;228(1):e13281.
doi: 10.1111/apha.13281. Epub 2019 May 3.

The importance of being rhythmic: Living in harmony with your body clocks

Charna Dibner  1   2   3   4
Affiliations
Review

The importance of being rhythmic: Living in harmony with your body clocks

Charna Dibner. Acta Physiol (Oxf). 2020 Jan.

Abstract

Circadian rhythms have developed in all light-sensitive organisms, including humans, as a fundamental anticipatory mechanism that enables proactive adaptation to environmental changes. The circadian system is organized in a highly hierarchical manner, with clocks operative in most cells of the body ensuring the temporal coordination of physiological processes. Circadian misalignment, stemming from modern life style, draws increasing attention due to its tight association with the development of metabolic, cardiovascular, inflammatory and mental diseases as well as cancer. This review highlights recent findings emphasizing the role of the circadian system in the temporal orchestration of physiology, with a particular focus on implications of circadian misalignment in human pathologies.

Keywords: circadian clock; circadian misalignment; continuous recording of circadian bioluminescence; human physiology.

PubMed Disclaimer

References

REFERENCES

    1. Albrecht U, Ripperger JA. Circadian clocks and sleep: impact of rhythmic metabolism and waste clearance on the brain. Trends Neurosci. 2018;41:677-688.
    1. Takahashi JS. Molecular architecture of the circadian clock in mammals. In: Sassone-Corsi P, Christen YA, eds. Time for Metabolism and Hormones. Cham, CH: Springer; 2016:13-24.
    1. Albrecht U. Timing to perfection: the biology of central and peripheral circadian clocks. Neuron. 2012;74:246-260.
    1. Dibner C, Schibler U, Albrecht U. The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol. 2010;72:517-549.
    1. Asher G, Sassone-Corsi P. Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock. Cell. 2015;161:84-92.

Publication types

LinkOut - more resources