Expanding the activity spectrum of antiviral agents

Aleksandr Ianevski¹, Petter I Andersen¹, Andres Merits², Magnar Bjørås³, Denis Kainov⁴

Affiliations

¹ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway.
² Institute of Technology, University of Tartu, Tartu 50090, Estonia.
³ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo 0027, Norway.
⁴ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway; Institute of Technology, University of Tartu, Tartu 50090, Estonia. Electronic address: denis.kainov@ntnu.no.

PMID: 30980905
DOI: 10.1016/j.drudis.2019.04.006

Review

Expanding the activity spectrum of antiviral agents

Aleksandr Ianevski et al. Drug Discov Today. 2019 May.

. 2019 May;24(5):1224-1228.

doi: 10.1016/j.drudis.2019.04.006. Epub 2019 Apr 10.

Authors

Aleksandr Ianevski¹, Petter I Andersen¹, Andres Merits², Magnar Bjørås³, Denis Kainov⁴

Affiliations

¹ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway.
² Institute of Technology, University of Tartu, Tartu 50090, Estonia.
³ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo 0027, Norway.
⁴ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway; Institute of Technology, University of Tartu, Tartu 50090, Estonia. Electronic address: denis.kainov@ntnu.no.

PMID: 30980905
DOI: 10.1016/j.drudis.2019.04.006

Abstract

Broad-spectrum antivirals (BSAs) are agents that inhibit replication of several human viruses. Here, we review 108 approved, investigational, and experimental BSAs, for which safety profiles in humans are available. The most effective and tolerable BSAs could reinforce the arsenal of available antiviral therapeutics pending the results of further pre-clinical and clinical studies.

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Expanding the activity spectrum of antiviral agents

Affiliations

Expanding the activity spectrum of antiviral agents

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources