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. 2020 Feb;18(2):514-516.e2.
doi: 10.1016/j.cgh.2019.04.020. Epub 2019 Apr 10.

Durability of Interferon-induced Hepatitis B Surface Antigen Seroclearance

Yali Wu  1 , Yali Liu  1 , Junfeng Lu  1 , Zhenhuan Cao  1 , Yi Jin  1 , Lina Ma  1 , Nan Geng  1 , Shan Ren  1 , Yanhong Zheng  1 , Chengli Shen  2 , Xinyue Chen  3
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Free article

Durability of Interferon-induced Hepatitis B Surface Antigen Seroclearance

Yali Wu et al. Clin Gastroenterol Hepatol. 2020 Feb.
Free article

Abstract

Hepatitis B surface antigen (HBsAg) seroclearance has been recommended as an optimal endpoint of antiviral treatment by the latest chronic hepatitis B management guideline.1 However, few reports investigated the durability of response after HBsAg seroclearance, because of a lower HBsAg seroclearance rate and the difficulty of obtaining a sufficient number of samples for analysis. Our center has made a long-term commitment to investigate the personalized antiviral therapy for chronic hepatitis B. More than 300 patients achieved HBsAg seroclearance by interferon (IFN)-based antiviral treatment. In this study, the durability and the effects of hepatitis B virus (HBV) surface antibody (Anti-HBs) level on relapse after HBsAg seroclearance were investigated.

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Comment in

  • Muddle and Mechanism of Hepatitis B Surface Antigen Seroclearance.
    Vyas AK, Jindal A. Vyas AK, et al. Clin Gastroenterol Hepatol. 2019 Nov;17(12):2621. doi: 10.1016/j.cgh.2019.04.049. Clin Gastroenterol Hepatol. 2019. PMID: 31653316 No abstract available.
  • Reply.
    Wu Y, Shen C, Chen X. Wu Y, et al. Clin Gastroenterol Hepatol. 2019 Nov;17(12):2621-2622. doi: 10.1016/j.cgh.2019.05.015. Clin Gastroenterol Hepatol. 2019. PMID: 31653317 No abstract available.

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