Axon Guidance Molecules Implicated in Early-Onset Obesity
- PMID: 30981443
- DOI: 10.1016/j.tins.2019.03.005
Axon Guidance Molecules Implicated in Early-Onset Obesity
Abstract
Maternal nutritional status and the early growth rates of offspring influence the development of the melanocortin system and later susceptibility to metabolic dysregulation, but it is difficult to assess causality. A recent study by van der Klaauw et al. (Cell 2019;176:729-742) provides direct evidence that disrupting systems regulating neuronal circuit formation leads to early-onset obesity in zebrafish, mouse, and humans.
Keywords: axon guidance; early-onset obesity; hypothalamus; plexins; semaphorins.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Comment on
-
Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.Cell. 2019 Feb 7;176(4):729-742.e18. doi: 10.1016/j.cell.2018.12.009. Epub 2019 Jan 17. Cell. 2019. PMID: 30661757 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources