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Comment
. 2019 Jul;42(7):439-440.
doi: 10.1016/j.tins.2019.03.005. Epub 2019 Apr 10.

Axon Guidance Molecules Implicated in Early-Onset Obesity

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Comment

Axon Guidance Molecules Implicated in Early-Onset Obesity

Lori M Zeltser. Trends Neurosci. 2019 Jul.

Abstract

Maternal nutritional status and the early growth rates of offspring influence the development of the melanocortin system and later susceptibility to metabolic dysregulation, but it is difficult to assess causality. A recent study by van der Klaauw et al. (Cell 2019;176:729-742) provides direct evidence that disrupting systems regulating neuronal circuit formation leads to early-onset obesity in zebrafish, mouse, and humans.

Keywords: axon guidance; early-onset obesity; hypothalamus; plexins; semaphorins.

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  • Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.
    van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O'Rahilly S, Simerly RB; INTERVAL; UK10K Consortium; Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS. van der Klaauw AA, et al. Cell. 2019 Feb 7;176(4):729-742.e18. doi: 10.1016/j.cell.2018.12.009. Epub 2019 Jan 17. Cell. 2019. PMID: 30661757 Free PMC article.

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