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Editorial
. 2019;49(5):410-412.
doi: 10.1159/000499864. Epub 2019 Apr 12.

Treating Systemic Klotho Deficiency

Johanne Pastor  1 , Orson W Moe  2   3   4
Affiliations
Editorial

Treating Systemic Klotho Deficiency

Johanne Pastor et al. Am J Nephrol. 2019.
No abstract available

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Figures

Fig. 1.
Fig. 1.
Existent methods to increase circulating Klotho levels. Recombinant Klotho protein can be given parentally to achieve adequate circulating levels. Klotho cDNA can be delivered. either as naked cDNA (full-length plasmid or minicircles) or encapsulated by adeno-associated virus. The majority of these reside in the liver and Klotho is released. The Klotho gene can be inserted into the genotype as a transgene with a strong promoter driving Klotho protein production. Finally, there are pharmacologic means to increase endogenous Klotho production. Statin: 3-hydroxy-3-methylglutaryl CoA reductase inhibitors. TZD or peroxisome proliferator-activated receptor-gamma agonists. The minicircle technology represents another version of Klotho cDNA. AAV, adeno-associated; PPAR-γ, peroxisome proliferator-activated receptor-gamma; ACEI, angiotensin-converting enzyme inhibitors; TZD, thiazolidinediones.
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Comment on

References

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