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. 2019 Jan 22;32(Suppl 1):7.
doi: 10.11604/pamj.supp.2019.32.1.13272. eCollection 2019.

Predictors of tuberculosis treatment success among HIV-TB co-infected patients attending major tuberculosis treatment sites in Abeokuta, Ogun State, Nigeria

Kayode Akanbi  1   2 , Ikeoluwapo Ajayi  3 , Samuel Fayemiwo  2 , Saheed Gidado  1 , Abisola Oladimeji  1 , Peter Nsubuga  4
Affiliations

Predictors of tuberculosis treatment success among HIV-TB co-infected patients attending major tuberculosis treatment sites in Abeokuta, Ogun State, Nigeria

Kayode Akanbi et al. Pan Afr Med J. .

Abstract

Introduction: tuberculosis (TB) is the commonest opportunistic infection and cause of death in patients with Human Immunodeficiency Virus (HIV) in developing countries. World Health Organization (WHO) recommends 85% treatment success rate for all TB cases as an indicator of TB control. The study aimed at determining TB treatment success rate among TB-HIV co-infected patients and identifying predictors of successful treatment among patients in TB treatment sites in Abeokuta, Nigeria.

Methods: it was a cross-sectional study among HIV-TB co-infected patients in the two major health facilities in Abeokuta, Nigeria. Socio-demographic characteristics with treatment history were obtained using a semi-structured questionnaire. Sputum samples were collected and tested for acid-fast bacilli (AFB) using a standard method according to national guideline for TB treatment to determine treatment success rate. Treatment success was defined as any HIV positive patient with a diagnosis of TB by acid-fast bacilli (AFB) smear positivity at diagnosis, who after 6 months of complete treatment becomes smear negative. Adjusted odds ratio was used to identify independent predictors of successful treatment outcome with confidence interval set at 95% and level of significance set at P < 0.05.

Results: a total of 109 HIV-TB co-infected patients were enrolled for this study. Fifty-nine (54.1%) were females, 106 (97.3%) were newly treated for TB. Eighty-five (78.0%) were treated in a private health facility. A total of 91 had successful treatment outcome with a treatment success rate (TSR) of 83.5%. Eleven (10.1%) died, 5 (4.6%) defaulted, 1 (0.9%) failed treatment, 1 (0.9%) was transferred out. Successful treatment was associated with being newly registered (i.e. receiving TB treatment under the DOTS program for the first time), receiving TB treatment for the first time (adjusted OR = 18, 95%CI: 1.5-482.3) and being treated at a private health facility (adjusted OR = 14.1, 95%CI 4.27-48.4).

Conclusion: treatment success rate of TB among HIV-TB co-infected patients in this study slightly falls below the WHO target. Registration status and health facility type were predictors of treatment outcome among study patients. Patients and healthcare workers in public facilities were educated on HIV-TB co-infection management.

Keywords: Abeokuta; HIV; Nigeria; Tuberculosis; treatment outcome.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
distribution of tuberculosis treatment outcome of HIV patients attending major treatment sites in Abeokuta, Ogun State - March 2014 to June 2015
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References

    1. Kingsley Chinedum Ochei by A review of community tuberculosis care intervention in Nigeria - A care study of NGO intervention - A Capstone Project - A Case Study. South Am J Public Heal. 2014;(21):2309–6470.
    1. Nik Nor Ronaidi NM, Mohd NS, Wan Mohammad Z, Sharina D, Nik Rosmawati NH. Factors associated with unsuccessful treatment outcome of pulmonary tuberculosis in Kota Bharu, Kelantan. Malaisaian Journal of Public heath. 2011;11(1):5.
    1. WHO . Tuberculosis and HIV. 2012. Accessed 2015 Jul 27.
    1. US Embassy Nigeria . Nigeria Tuberculosis Fact Sheet 2012. 2012. Accessed 2015 Jul 27.
    1. NTBLCP . Federal Ministry of Health Department of Public Health Workers’ Manual. 5. Vol. 5. National Tuberculosis and Leprosy Control Program; 2010. pp. 1–140.

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