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. 2019 Mar 29:7:121.
doi: 10.3389/fped.2019.00121. eCollection 2019.

Increased Incidence of Kawasaki Disease in Taiwan in Recent Years: A 15 Years Nationwide Population-Based Cohort Study

Ying-Hsien Huang  1   2   3 , Kuan-Miao Lin  3 , Shu-Chen Ho  4 , Jia-Huei Yan  3 , Mao-Hung Lo  1   2 , Ho-Chang Kuo  1   2
Affiliations

Increased Incidence of Kawasaki Disease in Taiwan in Recent Years: A 15 Years Nationwide Population-Based Cohort Study

Ying-Hsien Huang et al. Front Pediatr. .

Abstract

Background: Kawasaki disease (KD) is diagnosed in children suffering from fever for more than five days and five clinical characteristic symptoms. The aim of this article was to research the clinical characteristics among KD children in Taiwan in recent years through a population-based cohort study. Materials and Methods: We carried out a nationwide retrospective cohort study by analyzing the data of KD patients (ICD-9-CM code 4461) from Taiwan's National Health Insurance Research Database (NHIRD) during the period of 1996-2011. Results: Among all the insured children in the NHIRD, insurance claims data were reported for 13,260 patients diagnosed with KD, with 8394 (63.30%) subjects being administered IVIG for treatment. Of the patients diagnosed with KD, 94% were under the age of 5 years old, and the majority of cases occurred in May. Furthermore, the incidence of KD more than doubled (28.58-60.08 per 100,000) during this period in Taiwan. Conclusion: We developed a five-based mnemonic device for parents and first-line clinicians to easily use in order to diagnose KD. We also observed an increased incidence of KD in Taiwan during the study period. In addition, we develop a five-based mnemonic device for parents and first-line clinicians in clinical diagnosis of KD can easily remember: Fever> 5 days, 5 clinical criteria, predominantly in children <5 years of age, and peak seasonal clustering in the 5th month, May (April-June) in Taiwan.

Keywords: Kawasaki disease; Taiwan's National Health Insurance Research Database; cohort study; incidence; seasonality.

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Figures

Figure 1
Figure 1
The seasonality of Kawasaki disease in Taiwan.
Figure 2
Figure 2
The increased incidence of KD in recent years in Taiwan.
See this image and copyright information in PMC

References

    1. Kawasaki T, Kosaki F, Okawa S, Shigematsu I, Yanagawa H. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics. (1974) 54:271–6. - PubMed
    1. Wang CL, Wu YT, Liu CA, Kuo HC, Yang KD. Kawasaki disease: infection, immunity and genetics. Pediatr Infect Dis J. (2005) 24:998–1004. 10.1097/01.inf.0000183786.70519.fa - DOI - PubMed
    1. Kuo HC. Preventing coronary artery lesions in Kawasaki disease. Biomed J. (2017) 40:141–6. 10.1016/j.bj.2017.04.002 - DOI - PMC - PubMed
    1. Liang CD, Kuo HC, Yang KD, Wang CL, Ko SF. Coronary artery fistula associated with Kawasaki disease. Am Heart J. (2009) 157:584–8. 10.1016/j.ahj.2008.11.020 - DOI - PubMed
    1. Newburger JW, Takahashi M, Burns JC, Beiser AS, Chung KJ, Duffy CE, et al. . The treatment of Kawasaki syndrome with intravenous gamma globulin. N Engl J Med. (1986) 315:341–7. 10.1056/NEJM198608073150601 - DOI - PubMed