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Comment
. 2019 Apr 15;129(5):1836-1838.
doi: 10.1172/JCI128370.

Are we there yet? The never-ending quest for an Epstein-Barr virus vaccine

Sandhya Sharma, Rayne H Rouce
Comment

Are we there yet? The never-ending quest for an Epstein-Barr virus vaccine

Sandhya Sharma et al. J Clin Invest. .

Abstract

The Epstein-Barr virus (EBV) is estimated to infect a large part of the population and is associated with a variety of human tumors; therefore, EBV is an important target for vaccine development. In this issue of the JCI, Rühl et al. developed a promising heterologous prime-boost vaccination strategy for EBV-associated malignancies and symptomatic primary infection. The authors show that two prime-boost regimens, using either dendritic cells or an adenovirus approach targeting nuclear antigen EBNA1 followed by a modified vaccinia virus Ankara (MVA) booster, induced significant T cell-mediated, EBV-specific immune control and Ab production. These findings suggest that administration of heterologous prime-boost vaccinations targeting EBNA1 may result in potent CD4+ and CD8+ T cell-mediated EBV immune control and may be a promising clinical approach.

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Conflict of interest statement

Conflict of interest: The authors have declared that no conflict of interest exists.

Comment on

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