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. 2019 Jun 24;63(7):e00248-19.
doi: 10.1128/AAC.00248-19. Print 2019 Jul.

Body Surface Area-Based Dosing Regimen of Caspofungin in Children: a Population Pharmacokinetics Confirmatory Study

Xin-Mei Yang  1 , Stephanie Leroux  2   3 , Thomas Storme  2 , Dao-Lun Zhang  2 , Tiphaine Adam de Beaumais  4 , Hai-Yan Shi  1 , Yi-Lei Yang  1 , Xiao-Ling Wang  5 , Wei Zhao #  6   7 , Evelyne Jacqz-Aigrain #  8   9
Affiliations

Body Surface Area-Based Dosing Regimen of Caspofungin in Children: a Population Pharmacokinetics Confirmatory Study

Xin-Mei Yang et al. Antimicrob Agents Chemother. .

Abstract

We evaluated the population pharmacokinetics of caspofungin in children (2 to 12 years of age). The real-world data from 48 children were best fit by a two-compartment model with first-order elimination. Subsequent covariate analysis demonstrated that body surface area had a significant correlation with caspofungin pharmacokinetics, compared to body weight. The population pharmacokinetics of caspofungin confirmed that adjustment of caspofungin dosage based on body surface area is most appropriate for pediatric use.

Keywords: caspofungin; children; developmental pharmacokinetics; dose.

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Figures

FIG 1
FIG 1
Evaluation of caspofungin models. (A) Population predicted concentrations (PRED) versus observed concentrations (directly visualized [DV]). (B) Individual predicted concentrations (IPRED) versus observed concentrations. (C) CWRES versus time. (D) CWRES versus population predicted concentrations. (E) Quantile-quantile plot of the distribution of NPDEs versus the theoretical N(0,1) distribution. (F) Histogram of the distribution of NPDEs, overlaid with the density of a standard Gaussian distribution.
See this image and copyright information in PMC

References

    1. Schwartz M, Kline W, Matuszewski B. 1997. Determination of a cyclic hexapeptide (L-743 872), a novel pneumocandin antifungal agent in human plasma and urine by high-performance liquid chromatography with fluorescence detection. Anal Chim Acta 352:299–307. doi:10.1016/S0003-2670(97)00263-8. - DOI
    1. Sable CA, Strohmaier KM, Chodakewitz JA. 2008. Advances in antifungal therapy. Annu Rev Med 59:361–379. doi:10.1146/annurev.med.59.062906.071602. - DOI - PubMed
    1. Stone EA, Fung HB, Kirschenbaum HL. 2002. Caspofungin: an echinocandin antifungal agent. Clin Ther 24:351–377. doi:10.1016/S0149-2918(02)85039-1. - DOI - PubMed
    1. VandenBussche HL, Van Loo DA. 2010. A clinical review of echinocandins in pediatric patients. Ann Pharmacother 44:166–177. doi:10.1345/aph.1M139. - DOI - PubMed
    1. Walsh TJ, Adamson PC, Seibel NL, Flynn PM, Neely MN, Schwartz C, Shad A, Kaplan SL, Roden MM, Stone JA, Miller A, Bradshaw SK, Li SX, Sable CA, Kartsonis NA. 2005. Pharmacokinetics, safety, and tolerability of caspofungin in children and adolescents. Antimicrob Agents Chemother 49:4536–4545. doi:10.1128/AAC.49.11.4536-4545.2005. - DOI - PMC - PubMed

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