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. 1987 Jan 1;165(1):1-13.
doi: 10.1084/jem.165.1.1.

The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes

D J Paterson, J R Green, W A Jefferies, M Puklavec, A F Williams

The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes

D J Paterson et al. J Exp Med. .

Abstract

A monoclonal antibody called MRC OX-44 is described that labels all myeloid cells and peripheral lymphoid cells but only 12% of thymocytes. The OX-44+ thymic cells include most if not all cells found in the medulla but only a small fraction of the cortical cells. Together with CD4 and CD8 antigens, seven subsets of thymic cell were defined and it was notable that most CD4- CD8- cells were OX-44+ whereas almost all CD4+ CD8+ cells were OX-44-. In functional tests, the OX-44+ cells accounted for all proliferation by thymocytes when stimulated by allogeneic spleen cells or concanavalin A plus growth factors and OX-44- cells were completely negative in these assays. Also, in tests for thymopoiesis after intra-thymic injection of cells, all activity was OX-44+. It seems possible that the OX-44+ set may include all functionally relevant cells in the rat thymus.

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References

    1. J Immunol. 1981 Dec;127(6):2594-604 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Aug;76(8):4061-5 - PubMed
    1. J Cell Sci. 1972 Jan;10(1):27-46 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Jan;72(1):157-61 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1977;41 Pt 1:23-32 - PubMed

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