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. 1978;10(3):177-81.
doi: 10.3109/inf.1978.10.issue-3.04.

Serological diagnosis of pneumococcal disease with enzyme-linked immunosorbent assay (ELISA)

Serological diagnosis of pneumococcal disease with enzyme-linked immunosorbent assay (ELISA)

E Berntsson et al. Scand J Infect Dis. 1978.

Abstract

Antibody response to pneumococcal type-specific polysaccharide was measured with enzyme-linked immunosorbent assay (ELISA). The test was shown to be up to 500 times more sensitive than indirect hemagglutination using chromic chloride-treated red blood cells. In 16/17 patients with pneumococcal pneumonia a significant antibody increase was seen as measured with ELISA. Only 6/23 patients with pneumonia caused by Mycoplasma pneumoniae gave a pneumococcal antibody rise and in those cases the increase was very slight. The authors consider ELISA a valuable contribution to the serological diagnosis of pneumococcal disease.

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