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Comment
. 2019 Apr 15;35(4):542-544.
doi: 10.1016/j.ccell.2019.03.009.

Doomed from the TERT? A Two-Stage Model of Tumorigenesis in IDH-Wild-Type Glioblastoma

Lucy F Stead  1 , Roel G W Verhaak  2
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Doomed from the TERT? A Two-Stage Model of Tumorigenesis in IDH-Wild-Type Glioblastoma

Lucy F Stead et al. Cancer Cell. .
Free article

Abstract

Using longitudinal molecular profiling, Körber et al. propose in this issue of Cancer Cell that IDH-wild-type glioblastomas initiate years pre-diagnosis with chromosome-level alterations that drive cell proliferation but require survival-promoting mutations, commonly in the TERT promoter, to form a detectable tumor. Multiple subclones drive disease progression, creating a therapeutic challenge.

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