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. 2019 Apr 16;19(1):67.
doi: 10.1186/s12883-019-1285-7.

Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population

Ning Gao  1 , Tie Guo  2 , Han Luo  1 , Guolong Tu  1 , Fanglin Niu  3 , Mengdan Yan  3 , Ying Xia  4
Affiliations

Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population

Ning Gao et al. BMC Neurol. .

Abstract

Background: Stroke is a serious cardiovascular disease and is also the leading cause of long-term disability in developing and developed countries. Because matrix metalloproteinase-9 (MMP-9) is associated with the risk of many cardiovascular diseases, we investigated the relationship between single nucleotide polymorphisms (SNPs) in MMP-9 and the risk of Ischemic stroke (IS) in a southern Chinese Han population.

Methods: This study included 250 stroke patients and 250 healthy controls. Genotyping was performed using the Agena MassARRAY system, and chi-squared tests and genetic models were used to evaluate the associations between MMP-9 SNPs and the risk of IS. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for age.

Results: Polymorphism rs3787268 was associated with increased the risk of IS. Specifically, the genotype "G/A" significantly correlated with IS risk in the co-dominant model [odds ratio (OR) = 1.62; 95% confidence interval (CI) = 1.10-2.41; p = 0.035)], while genotypes "G/A" and "A/A" may increase the risk of IS based on the dominant model (OR = 1.62; 95% CI = 1.12-2.35; p = 0.0097). This SNP was also significantly associated with IS risk in the log-additive model (OR = 1.33; 95% CI = 1.03-1.70; p = 0.026). Conversely, haplotype "C/G" appears to reduce the risk of IS (OR = 0.71; 95% CI = 0.54-0.95; p = 0.019).

Conclusions: Our study showed that the rs3787268 locus in the MMP-9 gene may increase risk of IS in a southern Chinese Han population and thus provide insight into the IS pathogenesis.

Keywords: Case-control study; Ischemic stroke; MMP-9; Single nucleotide polymorphism.

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Conflict of interest statement

Ethics approval and consent to participate

The Ethic Committee of the Haikou Hospital affiliated to Xiangya Medical College of Central South University approved the use of human blood samples for this study. The purpose of this study was well informed to the subjects and written informed consent was obtained from each of them.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Haplotype block map for the four MMP-9 single nucleotide polymorphisms explored in our study
See this image and copyright information in PMC

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