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Comment
. 2019 Apr 16;10(2):e00542-19.
doi: 10.1128/mBio.00542-19.

Reply to Holmes and Duchêne, "Can Sequence Phylogenies Safely Infer the Origin of the Global Virome?": Deep Phylogenetic Analysis of RNA Viruses Is Highly Challenging but Not Meaningless

Yuri I Wolf  1 , Darius Kazlauskas  2   3 , Jaime Iranzo  4 , Adriana Lucía-Sanz  4   5 , Jens H Kuhn  6 , Mart Krupovic  3 , Valerian V Dolja  7 , Eugene V Koonin  4
Affiliations
Comment

Reply to Holmes and Duchêne, "Can Sequence Phylogenies Safely Infer the Origin of the Global Virome?": Deep Phylogenetic Analysis of RNA Viruses Is Highly Challenging but Not Meaningless

Yuri I Wolf et al. mBio. .
No abstract available

Keywords: RNA virome; RNA-dependent RNA polymerase; phylogenomics; virus classification; virus evolution.

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Figures

FIG 1
FIG 1
Sequence conservation profile along the core alignment of the RdRps and RTs. The homogeneity metric is based on the BLOSUM62 scores between the consensus amino acid and the actual amino acids in the alignment column and are scaled from 1 (all residues are the same) to 0 (the score is not different from the random expectation). The fraction of gaps is computed using sequence weights (6). The amino acids conserved in five prominent motifs are shown. The conservation of a residue is indicated as follows: bold uppercase letter, homogeneity of ≥0.9; uppercase letter, homogeneity of ≥0.75; lowercase letter, homogeneity of ≥0.3; x, homogeneity of <0.3.
See this image and copyright information in PMC

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References

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