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Review
. 2017 Aug 30;10(2):53-56.
doi: 10.1002/cld.653. eCollection 2017 Aug.

Patterns of necrosis in liver disease

Murli Krishna  1
Affiliations
Review

Patterns of necrosis in liver disease

Murli Krishna. Clin Liver Dis (Hoboken). .
No abstract available

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Figures

Figure 1
Figure 1
Apoptotic (acidophil) body (arrow). Note the condensation and dark staining of the cytoplasm and absence of nucleus.
Figure 2
Figure 2
Spotty necrosis. Several adjacent hepatocytes are absent and replaced by inflammatory cells.
Figure 3
Figure 3
Examples of zonal necrosis. (A) Bland CLN necrosis caused by ischemia. (B) Drug‐induced hepatitis with portal inflammation and CLN. (C) Venous outflow impairment with sinusoidal dilatation and CLN. (D) Massive hepatic necrosis, with involvement of all three zones and only sparse remaining periportal hepatocytes. Foci of confluent necrosis across multiple lobules are present. Arrows point to the central veins.
Figure 4
Figure 4
Interface hepatitis (IH) in a case of autoimmune hepatitis. The inflammatory infiltrate extends from the portal tract (PT) into the lobule, with destruction of the limiting plate of hepatocytes. Bridging fibrosis (BF) is also present.
See this image and copyright information in PMC

References

    1. Ludwig J, Batts K. Practical Liver Biopsy Interpretation: Diagnostic Algorithms. 2nd ed. Chicago: ASCP Press; 1998.
    1. Lefkowitch JH. Scheuer's Liver Biopsy Interpretation. 8th ed. Saunders Elsevier; 2010.
    1. Lefkowitch JH. Liver biopsy assessment in chronic hepatitis. Arch Med Res 2007;38:634‐643. - PubMed
    1. Manns MP, Czaja AJ, Gorham JD, Krawitt EL, Mieli‐Vergani G, Vergani D, et al. Diagnosis and management of autoimmune hepatitis. Hepatology 2010;51:2193‐2213. - PubMed
    1. Fisher K, Vuppalanchi R, Saxena R. Drug‐induced liver injury. Arch Pathol Lab Med 2015;139:876‐887. - PubMed