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Review
. 2017 Nov 30;10(5):116-119.
doi: 10.1002/cld.671. eCollection 2017 Nov.

The gut microbiome and nonalcoholic fatty liver disease

Brian A Nadeau  1 , Hari Conjeevaram  1
Affiliations
Review

The gut microbiome and nonalcoholic fatty liver disease

Brian A Nadeau et al. Clin Liver Dis (Hoboken). .
No abstract available

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Figures

Figure 1
Figure 1
Key factors and pathways involved in the establishment and progression of NAFLD to hepatic fibrosis. Genetics and a high‐fat diet contribute to insulin resistance and an increase in plasma free fatty acids, which can lead to the development of the metabolic syndrome. These factors contribute to dysbiosis of the gut microbiome and increased gut epithelial permeability. The compromised intestinal barrier allows gut translocation of proinflammatory cytokines, ethanol produced from gut bacteria, and LPS derived from the cell wall of gram‐negative bacteria. Delivery of gut‐derived substances directly to the liver via the portal circulation results in an inflammatory cascade with resultant hepatic inflammation and development of NASH in some patients with NAFL. This results in hepatocyte death and activation of hepatic stellate cells, which leads to collagen deposition and subsequent liver fibrosis in a subset of patients with NASH.
See this image and copyright information in PMC

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