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. 2014 Apr 1;3(3):52-55.
doi: 10.1002/cld.320. eCollection 2014 Mar.

Diagnosis and management of patients with primary biliary cirrhosis

Jessica Dyson  1 , David Jones  2
Affiliations

Diagnosis and management of patients with primary biliary cirrhosis

Jessica Dyson et al. Clin Liver Dis (Hoboken). .
No abstract available

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Figures

Figure 1
Figure 1
Immunofluorescence patterns in ANAs. Representative AMA and ANA indirect immunofluorescence staining patterns are shown: AMA staining in (A) a rat liver, (B) the Hep2 cell line, (C) rat gastric parietal cells, and (D) a rat kidney; ANA staining in (E) homogeneous nuclear and (F) nuclear rimlike patterns in the Hep2 cell line; and peripheral staining in (G) the Hep2 cell line and (H) rat liver cells.
Figure 2
Figure 2
Biopsy images: PBC versus predominant AIH. (A) Destructive cholangitis (arrow) and mild mixed portal inflammatory infiltrate with focal interface activity (arrowheads) in PBC (hematoxylin and eosin, ×10). The inset shows characteristic granulomatous cholangitis and a dense lymphoplasmacytic infiltrate involving another portal tract (hematoxylin and eosin, ×20). (B) Autoimmune cholangiopathy with features suggestive of overlap with AIH. This indicates that steroid use may be appropriately considered: moderate, predominantly plasmacytic, chronic inflammation in the portal tract and focal lymphocytic cholangitis (white arrows) with mild degenerative changes in the interlobular bile duct epithelium; moderate interface activity (white arrowheads) including plasma cells; and zone 1 spotty necrosis (black arrow; hematoxylin and eosin, ×20). The inset shows evidence of chronic cholestasis with dark brown intracytoplasmic granules of copper‐associated protein in periportal hepatocytes (black arrowheads; orcein, ×40).
Figure 3
Figure 3
Flowchart providing simple guidance for the diagnosis of PBC.
Figure 4
Figure 4
Factors contributing to fatigue in PBC.
See this image and copyright information in PMC

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