Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jul 25;4(1):17-21.
doi: 10.1002/cld.373. eCollection 2014 Jul.

Acetaminophen overdose: What practitioners need to know

Khurram Bari  1 , Robert J Fontana  1
Affiliations
Review

Acetaminophen overdose: What practitioners need to know

Khurram Bari et al. Clin Liver Dis (Hoboken). .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Modified Rumack‐Matthew nomogram in APAP overdose. The modified Rumack‐Matthew nomogram should only be used in patients with one time‐point APAP ingestion. Subjects with a serum APAP level above the line are at risk for developing hepatotoxicity and should be hospitalized and given NAC for a minimum of 24 hours. The serum APAP level should be plotted in relationship to the estimated time of oral ingestion and should be repeated 4 hours after presentation in subjects with an unreliable history. The nomogram should not be used in ingestions that occurred > 24 hours prior to presentation or in patients who have overdosed over several days. This figure has been adapted from N Engl J Med.4
See this image and copyright information in PMC

References

    1. Nourjah P, Ahmad SR, Karwoski C, Willy M. Estimates of acetaminophen (Paracetomal)‐associated overdoses in the United States. Pharmacoepidemiol Drug Saf 2006;15(6):398‐405. - PubMed
    1. Myers RP1, Li B, Fong A, Shaheen AA, Quan H. Hospitalizations for acetaminophen overdose: a Canadian population‐based study from 1995 to 2004. BMC Public Health 2007;7:143. - PMC - PubMed
    1. Larson AM, Polson J, Fontana RJ, et al. Acetaminophen‐induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005;42(6):1364‐1372. - PubMed
    1. Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral N‐acetylcysteine in the treatment of acetaminophen overdose. N Engl J Med 1988;319:1557‐1562. - PubMed
    1. Davern TJ, James LP, Hinson JA, et al. Measurement of serum acetaminophen–protein adducts in patients with acute liver failure. Gastroenterology 2006;130:687‐694. - PubMed