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. 2014 Sep 26;4(3):69-73.
doi: 10.1002/cld.409. eCollection 2014 Sep.

Preeclampsia-induced Liver Dysfunction, HELLP syndrome, and acute fatty liver of pregnancy

Ghassan M Hammoud  1 , Jamal A Ibdah  1
Affiliations

Preeclampsia-induced Liver Dysfunction, HELLP syndrome, and acute fatty liver of pregnancy

Ghassan M Hammoud et al. Clin Liver Dis (Hoboken). .
No abstract available

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Figures

Figure 1
Figure 1
Liver in HELLP syndrome. (A) Periportal patchy hemorrhage and necrosis (arrow). (B) Sinusoidal deposition of fibrin (arrow); hematoxylin and eosin stain. Reproduced with permission from Hammoud.13
Figure 2
Figure 2
Hypothesis illustrating the possible role of fetal and maternal mitochondrial trifunctional protein mutations in developing AFLP. (A) Carrying an LCHAD‐deficient fetus is the major determining factor in the development of maternal illness. Hepatotoxic metabolites produced by the fetus and/or placenta may cause liver disease in the obligate heterozygous mother when combined with the metabolic stress of the third trimester. (B) Environmental stress may lead to the further accumulation of toxic metabolites in the genetically susceptible mother, causing maternal liver disease. Reproduced with permission from Hammoud.13
Figure 3
Figure 3
Acute fatty liver of pregnancy. Fat accumulation is greater in pericentral hepatocytes (arrow) compared with periportal hepatocytes (arrowhead); hematoxylin and eosin stain. Reproduced with permission from Hammoud.13
See this image and copyright information in PMC

References

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