Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Apr 5:7:10.
doi: 10.1186/s41038-019-0148-1. eCollection 2019.

Advances in surgical applications of growth factors for wound healing

Sho Yamakawa  1 , Kenji Hayashida  1
Affiliations
Review

Advances in surgical applications of growth factors for wound healing

Sho Yamakawa et al. Burns Trauma. .

Abstract

Growth factors have recently gained clinical importance for wound management. Application of recombinant growth factors has been shown to mimic cell migration, proliferation, and differentiation in vivo, allowing for external modulation of the healing process. Perioperative drug delivery systems can enhance the biological activity of these growth factors, which have a very short in vivo half-life after topical administration. Although the basic mechanisms of these growth factors are well understood, most have yet to demonstrate a significant impact in animal studies or small-sized clinical trials. In this review, we emphasized currently approved growth factor therapies, including a sustained release system for growth factors, emerging therapies, and future research possibilities combined with surgical procedures. Approaches seeking to understand wound healing at a systemic level are currently ongoing. However, further research and consideration in surgery will be needed to provide definitive confirmation of the efficacy of growth factor therapies for intractable wounds.

Keywords: Growth factor; Surgical application; Wound healing.

PubMed Disclaimer

Conflict of interest statement

Consent for inclusion in the Shimane University Hospital Registry includes the possibility of publication of information for research purposes.Not applicable.The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Pressure ulcer debridement. a This is a highly infected sacral pressure ulcer. Prior to the application of any growth factors, contaminated wounds should be meticulously and completely debrided. b This is the same pressure ulcer after debridement. Debridement of pressure ulcers is a safe and effective technique to make growth factor receptors respond to exogenous topical treatment
Fig. 2
Fig. 2
Biological and clinical aspect of growth factors
See this image and copyright information in PMC

References

    1. Park JW, Hwang SR, Yoon IS. Advanced growth factor delivery systems in wound management and skin regeneration. Molecules. 2017;22:E1259. - PMC - PubMed
    1. Trengove NJ, Bielefeldt-Ohmann H, Stacey MC. Mitogenic activity and cytokine levels in non-healing and healing chronic leg ulcers. Wound Repair Regen. 2000;8:13–25. doi: 10.1046/j.1524-475x.2000.00013.x. - DOI - PubMed
    1. Brown LF, Yeo KT, Berse B, Yeo TK, Senger DR, Dvorak HF, et al. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med. 1992;176:1375–1379. doi: 10.1084/jem.176.5.1375. - DOI - PMC - PubMed
    1. Powers CJ, McLeskey SW, Wellstein A. Fibroblast growth factors, their receptors and signaling. Endocr Relat Cancer. 2000;7:165–197. doi: 10.1677/erc.0.0070165. - DOI - PubMed
    1. Marck RE, Gardien KLM, Vlig M, Breederveld RS, Middelkoop E. Growth factor quantification of platelet-rich plasma in burn patients compared to matched healthy volunteers. Int J Mol Sci. 2019;20:E288. - PMC - PubMed