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. 2019 Jan 14;4(4):603-606.
doi: 10.1016/j.ekir.2019.01.001. eCollection 2019 Apr.

Cumulative Exposure to Frequent Intradialytic Hypotension Associates With New-Onset Dementia Among Elderly Hemodialysis Patients

Magdalene M Assimon  1 , Lily Wang  2 , Jennifer E Flythe  1   3
Affiliations

Cumulative Exposure to Frequent Intradialytic Hypotension Associates With New-Onset Dementia Among Elderly Hemodialysis Patients

Magdalene M Assimon et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Association between time-updated, cumulative exposure to frequent intradialytic hypotension and the 5-year risk of new-onset dementia. We used marginal structural Fine and Gray proportional subdistribution hazard models, treating death as a competing event, to estimate association between the time-updated, cumulative exposure to frequent intradialytic hypotension and the 5-year risk of new-onset dementia. Within a given 90-day exposure interval, we classified an individual as having frequent intradialytic hypotension if he or she experienced a nadir intradialytic systolic blood pressure <90 mm Hg in at least 30% of hemodialysis treatments. Supplementary Table S3 contains outcome and competing event definitions. We used inverse probability of exposure weighting to adjust for baseline and time-updated covariates listed in Supplementary Table S4. CI, confidence interval; HR, hazard ratio.
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