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Review
. 2019 Jun;16(3):214-223.
doi: 10.1007/s11904-019-00442-9.

Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection

Emily Bowman  1 , Nicholas T Funderburg  2
Affiliations
Review

Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection

Emily Bowman et al. Curr HIV/AIDS Rep. 2019 Jun.

Abstract

Purpose of review: Human immunodeficiency virus (HIV) infection and its treatment with antiretroviral therapy (ART) are associated with lipid abnormalities that may enhance cardiovascular disease risk (CVD).

Recent findings: Chronic inflammation persists in HIV+ individuals, and complex relationships exist among lipids and inflammation, as immune activation may be both a cause and a consequence of lipid abnormalities in HIV infection. Advances in mass spectrometry-based techniques now allow for detailed measurements of individual lipid species; improved lipid measurement might better evaluate CVD risk compared with the prognostic value of traditional assessments. Lipidomic analyses have begun to characterize dynamic changes in lipid composition during HIV infection and following treatment with ART, and further investigation may identify novel lipid biomarkers predictive of adverse outcomes. Developing strategies to improve management of comorbidities in the HIV+ population is important, and statin therapy and lifestyle modifications, including diet and exercise, may help to improve lipid levels and mitigate CVD risk.

Keywords: Cardiovascular disease; Free fatty acids; HIV; Inflammation; Lipidome.

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Conflict of interest statement

Conflict of Interest

Dr. Bowman declares that she has no conflict of interest.

Dr. Funderburg serves as a consultant for Gilead.

Figures

Figure 1.
Figure 1.
Lipid abnormalities and enhanced CVD risk in HIV+ individuals may be driven by HIV itself, its treatment with ART, or the immunologic consequences associated with chronic HIV-infection
See this image and copyright information in PMC

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