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. 1986 Dec 15;44(6):859-66.
doi: 10.1016/0049-3848(86)90031-9.

The influence of glutathione and other thiols on human platelet aggregation

G Thomas, V A Skrinska, F V Lucas

The influence of glutathione and other thiols on human platelet aggregation

G Thomas et al. Thromb Res. .

Abstract

The platelet membrane contains sulfhydryl groups which are essential for normal platelet function. Reduced glutathione (GSH) and other thiols such as cysteine and 6-mercaptopurine were found to inhibit human platelet aggregation induced by adenosine diphosphate (ADP), collagen and arachidonic acid. The inhibition of ADP-induced aggregation by GSH (IC50 = 0.61 +/- 0.05 mM) was greater than that by cysteine (IC50 = 13 +/- 1 mM) or 6-mercaptopurine (IC50 = 5.4 +/- 0.2 mM). Two other thiols, dithiothreitol and beta-mercaptoethanol were found to cause platelet aggregation instead of inhibition. The interaction of GSH with the ADP receptor was noncompetitive in nature.

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