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Comparative Study
. 2019 Sep;30(6):461-466.
doi: 10.1097/MCA.0000000000000752.

Association between circulating big endothelin-1 and noncalcified or mixed coronary atherosclerotic plaques

Fang Wang  1 , Tiewei Li  1 , Xiangfeng Cong  1 , Zhihui Hou  2 , Bin Lu  2 , Zhou Zhou  1 , Xi Chen  1
Affiliations
Comparative Study

Association between circulating big endothelin-1 and noncalcified or mixed coronary atherosclerotic plaques

Fang Wang et al. Coron Artery Dis. 2019 Sep.

Abstract

Background: Noncalcified plaques (NCPs) and mixed plaques (MPs) are considered as the high-risk coronary plaques. Endothelin-1 (ET-1) is a vasoactive peptide and shows a high expression in vulnerable plaque. The aim of this study is to investigate the relationship between the bigET-1, the precursor of ET-1, and NCPs/MPs in a Chinese population.

Methods and results: A total of 513 patients with chest pain and suspected coronary artery disease were collected and divided into three groups with no plaques, calcified plaques, or NCPs/MPs according to the characteristics of all the plaques. It demonstrated that NCPs/MPs were associated with elevated bigET-1 (P < 0.001). Moreover, the proportion of NCPs/MPs was significantly increased from 43.3% in bigET-1 tertile 1 to 61.0% in tertile 3 group (P = 0.001). Multiple logistic regression analysis further showed that bigET-1 was an independent predictor for the presence of NCPs/MPs (odds ratio = 1.858; 95% confidence interval: 1.017-3.394; P = 0.044).

Conclusion: The bigET-1 could be an independent predictor for the presence of NCPs/MPs.

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Figures

Fig. 1
Fig. 1
The correlation of bigET-1 with BUN, CREA, hsCRP, TC, HDL-C, LDL-C TG and URIC. BigET-1 level was positively correlated with BUN, CREA and hsCRP (a-c) but inversely correlated with TC, HDL-C and LDL-C (d-f) and not correlated with TG and URIC (g,h). BigET-1, Big Endothelin-1; BUN, blood urea nitrogen; CREA, creatinine; hsCRP, high sensitivity C-reactive protein; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TG, triglycerides; URIC, uric acid.
See this image and copyright information in PMC

References

    1. Kolodgie FD, Virmani R, Burke AP, Farb A, Weber DK, Kutys R, et al. Pathologic assessment of the vulnerable human coronary plaque. Heart. 2004; 90:1385–1391 - PMC - PubMed
    1. Stone GW, Maehara A, Lansky AJ, de Bruyne B, Cristea E, Mintz GS, et al. A prospective natural-history study of coronary atherosclerosis. N Engl J Med. 2011; 364:226–235 - PubMed
    1. Narula J, Nakano M, Virmani R, Kolodgie FD, Petersen R, Newcomb R, et al. Histopathologic characteristics of atherosclerotic coronary disease and implications of the findings for the invasive and noninvasive detection of vulnerable plaques. J Am Coll Cardiol. 2013; 61:1041–1051 - PMC - PubMed
    1. Vazquez-Figueroa JG, Rinehart S, Qian Z, Joshi PH, Sharma A, Lee J, et al. Prospective validation that vulnerable plaque associated with major adverse outcomes have larger plaque volume, less dense calcium, and more non-calcified plaque by quantitative, three-dimensional measurements using intravascular ultrasound with radiofrequency backscatter analysis: results from the ATLANTA I Study. J Cardiovasc Transl Res. 2013; 6:762–771 - PMC - PubMed
    1. Hou ZH, Lu B, Gao Y, Jiang SL, Wang Y, Li W, Budoff MJ. Prognostic value of coronary CT angiography and calcium score for major adverse cardiac events in outpatients. JACC Cardiovasc Imaging. 2012; 5:990–999 - PubMed

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