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Case Reports
. 2020 Aug;42(6):e459-e462.
doi: 10.1097/MPH.0000000000001488.

A Case of Childhood Blastic Phase Chronic Myeloid Leukemia With Minor BCR-ABL

Junko Yamanaka  1 , Mariko Shimizu  2 , Maho Sato  2 , Masami Inoue  2 , Motohiro Matsui  3 , Hiroyuki Shimada  4 , Hiroyuki Shichino  1
Affiliations
Case Reports

A Case of Childhood Blastic Phase Chronic Myeloid Leukemia With Minor BCR-ABL

Junko Yamanaka et al. J Pediatr Hematol Oncol. 2020 Aug.

Abstract

Chronic myeloid leukemia (CML) is commonly associated with major BCR-ABL transcript. We present a child with blastic phase CML associated with minor BCR-ABL transcript without prior CML diagnosis. Diagnosis was achieved by fluorescence in situ hybridization of peripheral blood neutrophils, which identified 90% as BCR-ABL positive. The patient received chemotherapy with imatinib followed by dasatinib and underwent reduced-intensity hematopoietic allogeneic stem cell transplantation with prophylactic posttransplant dasatinib for 2 years and has remained in complete molecular remission. Our intensified treatment regimen was effective compared with previous studies on minor BCR-ABL CML describing inferior outcomes with tyrosine kinase inhibitor therapy.

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