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. 2019 May 24;82(5):1377-1381.
doi: 10.1021/acs.jnatprod.8b01032. Epub 2019 Apr 17.

Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

Hikaru Kato  1 , Momona Sebe  1 , Mika Nagaki  1 , Keisuke Eguchi  1 , Ippei Kagiyama  1 , Yuki Hitora  1 , Jens C Frisvad  2 , Robert M Williams  3   4 , Sachiko Tsukamoto  1
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Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

Hikaru Kato et al. J Nat Prod. .

Abstract

Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.

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