Modern Inflammatory Phenotyping of Asthma. Breathomics Is Here to Stay

Affiliations

Comment

Peter J Sterk. Am J Respir Crit Care Med. 2019.

. 2019 Aug 15;200(4):405-406.

doi: 10.1164/rccm.201904-0733ED.

No abstract available

Comment on

Exhaled Volatile Organic Compounds Are Able to Discriminate between Neutrophilic and Eosinophilic Asthma.
Schleich FN, Zanella D, Stefanuto PH, Bessonov K, Smolinska A, Dallinga JW, Henket M, Paulus V, Guissard F, Graff S, Moermans C, Wouters EFM, Van Steen K, van Schooten FJ, Focant JF, Louis R. Schleich FN, et al. Am J Respir Crit Care Med. 2019 Aug 15;200(4):444-453. doi: 10.1164/rccm.201811-2210OC. Am J Respir Crit Care Med. 2019. PMID: 30973757

1. Chung KF. Asthma phenotyping: a necessity for improved therapeutic precision and new targeted therapies. J Intern Med. 2016;279:192–204. - PubMed
1. Petsky HL, Cates CJ, Kew KM, Chang AB. Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils): a systematic review and meta-analysis. Thorax. 2018;73:1110–1119. - PubMed
1. Kuo CS, Pavlidis S, Loza M, Baribaud F, Rowe A, Pandis I, et al. U-BIOPRED Study Group. T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED. Eur Respir J. 2017;49:1602135. - PubMed
1. Schofield JPR, Burg D, Nicholas B, Strazzeri F, Brandsma J, Staykova D, et al. U-BIOPRED Study Group. Stratification of asthma phenotypes by airway proteomic signatures. J Allergy Clin Immunol. [online ahead of print] 27 Mar 2019; DOI: 10.1016/j.jaci.2019.03.013. - PubMed
1. Hulsen T, Jamuar SS, Moody AR, Karnes JH, Varga O, Hedensted S, et al. From big data to precision medicine. Front Med (Lausanne) 2019;6:34. - PMC - PubMed