Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Oct;103(2):151-155.
doi: 10.1016/j.jhin.2019.04.004. Epub 2019 Apr 14.

Antimicrobial-resistant Gram-negative colonization in infants from a neonatal intensive care unit in Thailand

T Roberts  1 , D Limmathurotsakul  2 , P Turner  3 , N P J Day  2 , W P Vandepitte  4 , B S Cooper  2
Affiliations

Antimicrobial-resistant Gram-negative colonization in infants from a neonatal intensive care unit in Thailand

T Roberts et al. J Hosp Infect. 2019 Oct.

Abstract

Antimicrobial-resistant Gram-negative bacteria are a major cause of morbidity and mortality in hospitalized neonates in South and South-East Asia. This study aimed to determine the dynamics of colonization with antimicrobial-resistant Gram-negative bacteria amongst patients in a neonatal intensive care unit (NICU) in Thailand. From 97 enrolled patients, 52% were colonized by an extended-spectrum β-lactamase (ESBL) organism at some point during their stay and 64% were colonized by a carbapenem-resistant organism. Rapid acquisition of ESBL-positive and carbapenem-resistant organisms was found. Once colonized with an antibiotic-resistant organism, patients remained colonized for the remainder of their NICU stay.

Keywords: Antimicrobial resistance; Carbapenem resistance; Colonization; Extended-spectrum beta-lactamase; Neonate.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(A) Number of patients who had samples taken and the number of each different sample type taken by days since admission. Dotted line, number of samples taken; bold line, rectal swabs taken; fine line, stools taken; dashed line, tracheal swabs taken. (B) Percentage of samples that grew an extended-spectrum beta-lactamase (ESBL)-positive organism by days since admission (vertical lines show 95% confidence intervals). (C) Percentage of samples that grew an imipenem-resistant (IPM-R) organism by days since admission (vertical lines show 95% confidence intervals).
See this image and copyright information in PMC

References

    1. World Health Organization . WHO; Geneva: 2017. Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics.
    1. Hongsuwan M., Srisamang P., Kanoksil M., Luangasanatip N., Jatapai A., Day N.P. Increasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast Thailand: a multicenter surveillance study. PLoS One. 2014;9 - PMC - PubMed
    1. Chereau F., Opatowski L., Tourdjman M., Vong S. Risk assessment for antibiotic resistance in South East Asia. BMJ. 2017;358:j3393. - PMC - PubMed
    1. Lim C., Takahashi E., Hongsuwan M., Wuthiekanun V., Thamlikitkul V., Hinjoy S. Epidemiology and burden of multidrug-resistant bacterial infection in a developing country. eLife. 2016;5 - PMC - PubMed
    1. Tong S.Y., Holden M.T., Nickerson E.K., Cooper B.S., Koser C.U., Cori A. Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting. Genome Res. 2015;25:111–118. - PMC - PubMed

Substances