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Comment
. 2019 Apr 16;50(4):1024-1026.
doi: 10.1016/j.immuni.2019.03.006.

Thrombin: A Gas Pedal Driving Innate Immunity

Tobias Petzold  1 , Steffen Massberg  2
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Thrombin: A Gas Pedal Driving Innate Immunity

Tobias Petzold et al. Immunity. .
Free article

Abstract

Hemostasis and immunity were long considered entirely separate entities. In this issue of Immunity, Burzynski et al. (2019) find that thrombin, the key enzyme within the coagulation cascade, activates IL-1α, a central pleiotropic pro-inflammatory cytokine, to promote wound healing and platelet production following ectoderm injury.

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