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. 2019 Apr 16;50(4):1026-1028.
doi: 10.1016/j.immuni.2019.03.015.

An X-ray Vision for Phosphoantigen Recognition

Michael L Dustin  1 , Emmanuel Scotet  2 , Daniel Olive  3
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An X-ray Vision for Phosphoantigen Recognition

Michael L Dustin et al. Immunity. .
Free article

Abstract

Invariant Vγ9Vδ2 T cells respond to "phosphoantigen" metabolites through binding to the B30.2 domain of butyrophilin BTN3A. Yang et al. (2019) use molecular dynamic simulations based on X-ray structures of distinct B30.2 domain dimers to identify the asymmetric dimer as most active, which has implications for the inside-out signaling mechanism.

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