Comment
doi: 10.1016/j.immuni.2019.03.019.
Becalming Type 17 Inflammation in Ulcerative Colitis
Affiliations
- PMID: 30995495
- DOI: 10.1016/j.immuni.2019.03.019
Item in Clipboard
Comment
Becalming Type 17 Inflammation in Ulcerative Colitis
Immunity.
.
Free article
Abstract
Genome-wide association studies in ulcerative colitis point to a role for FcγRIIA, a receptor for IgG. Castro-Dopico et al. (2019) find a profound induction of anti-commensal IgG in the colonic mucosa of UC patients and outline a pathway whereby FcγR activation by IgG triggers IL-1β production, type 17 immunity, and the exacerbation of inflammation.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
-
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.Immunity. 2019 Apr 16;50(4):1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006. Epub 2019 Mar 12. Immunity. 2019. PMID: 30876876 Free PMC article.
Dataset described in
-
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.Immunity. 2019 Apr 16;50(4):1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006. Epub 2019 Mar 12. Immunity. 2019. PMID: 30876876 Free PMC article.
Similar articles
-
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.Immunity. 2019 Apr 16;50(4):1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006. Epub 2019 Mar 12. Immunity. 2019. PMID: 30876876 Free PMC article.
-
Mucosal CXCR4+ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14 macrophage activation.Gut. 2013 Dec;62(12):1734-44. doi: 10.1136/gutjnl-2012-303063. Epub 2012 Sep 26. Gut. 2013. PMID: 23013725
-
Mucosal IgG in inflammatory bowel disease - a question of (sub)class?Gut Microbes. 2020 Nov 9;12(1):1-9. doi: 10.1080/19490976.2019.1651596. Epub 2019 Sep 3. Gut Microbes. 2020. PMID: 31480888 Free PMC article.
-
[Distribution of cells containing different IgG and IgA subclasses in the colonic mucosa in childhood ulcerative colitis and Crohn disease].Orv Hetil. 1991 Sep 15;132(37):2027-31. Orv Hetil. 1991. PMID: 1923475 Review. Hungarian.
-
IgG and Fcγ Receptors in Intestinal Immunity and Inflammation.Front Immunol. 2019 Apr 12;10:805. doi: 10.3389/fimmu.2019.00805. eCollection 2019. Front Immunol. 2019. PMID: 31031776 Free PMC article. Review.
Cited by
-
Inhibition of the activation of γδT17 cells through PPARγ-PTEN/Akt/GSK3β/NFAT pathway contributes to the anti-colitis effect of madecassic acid.Cell Death Dis. 2020 Sep 14;11(9):752. doi: 10.1038/s41419-020-02969-x. Cell Death Dis. 2020. PMID: 32929062 Free PMC article.
-
Inflammatory Bowel Disease: A Comprehensive Analysis of Molecular Bases, Predictive Biomarkers, Diagnostic Methods, and Therapeutic Options.Int J Mol Sci. 2024 Jun 27;25(13):7062. doi: 10.3390/ijms25137062. Int J Mol Sci. 2024. PMID: 39000169 Free PMC article. Review.
-
The potential mechanism of huazhuojiedu decoction in the treatment of ulcerative colitis based on network pharmacology and experimental validation.Front Pharmacol. 2022 Oct 14;13:1033874. doi: 10.3389/fphar.2022.1033874. eCollection 2022. Front Pharmacol. 2022. PMID: 36313293 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
