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Comment
. 2019 Apr 16;50(4):1029-1031.
doi: 10.1016/j.immuni.2019.03.019.

Becalming Type 17 Inflammation in Ulcerative Colitis

Hannah H Chen  1 , Alison Simmons  2
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Becalming Type 17 Inflammation in Ulcerative Colitis

Hannah H Chen et al. Immunity. .
Free article

Abstract

Genome-wide association studies in ulcerative colitis point to a role for FcγRIIA, a receptor for IgG. Castro-Dopico et al. (2019) find a profound induction of anti-commensal IgG in the colonic mucosa of UC patients and outline a pathway whereby FcγR activation by IgG triggers IL-1β production, type 17 immunity, and the exacerbation of inflammation.

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