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. 2019 Jun;18(2):224-228.
doi: 10.1007/s12663-018-1153-9. Epub 2018 Sep 29.

Spontaneous Regeneration of Bone in Segmental Mandibular Defect

Sachin Rai  1 , Vidya Rattan  1 , Satnam Singh Jolly  1 , Vinay Kumar Sharma  2 , Mohammad Muneeb Mubashir  1
Affiliations

Spontaneous Regeneration of Bone in Segmental Mandibular Defect

Sachin Rai et al. J Maxillofac Oral Surg. 2019 Jun.

Abstract

Aim: To highlight the spontaneous regeneration of mandibular segmental defects in young and pediatric cases and to review the literature of this unusual and rare phenomenon.

Methodology: Two case reports of a 17-year old male and a 8-month-old infant has been presented who underwent resection of mandible for benign tumors. These two cases have been compared with the existing literature of 61 cases published till date.

Inference: Spontaneous regeneration of mandible as a viable reconstructive option is not practically feasible. The consistency and predictability of the phenomenon is questionable. Bone grafting should probably be done immediately in all cases, even in young patients if a delay would interfere with quality of life. In infants and small children though, we propose that immediate reconstruction may be avoided to allow some regeneration at the defect site. If it does not occur, secondary reconstruction may then be considered.

Keywords: Pediatric jaw tumors; Periosteal regeneration; Reconstruction of mandible; Resection of mandible; Spontaneous regeneration.

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Conflict of interest statement

No conflict exists. Both the authors, Sachin Rai and Vidya Rattan, declare that they have no conflict of interest.This is an observational study conducted after routine surgery and did not need ethical approval. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.Informed consent was obtained from all individual participants included in the study to publish their postoperative results and pictures.

Figures

Fig. 1
Fig. 1
a Osteolytic lesion in the right body of the mandible extending up to the condyle and coronoid process. b, c Immediate postoperative radiograph depicting reconstruction of the dentate segment with iliac crest and titanium reconstruction plate (b). Postoperative radiograph after 6 months depicting spontaneous regeneration of the ramus–condyle–coronoid unit (c). d, e Coronal CBCT section of the condyle showing engulfing of the titanium condylar head with the regenerated bone (d). Postoperative radiograph at 3 years showing consolidated bone. A part of the reconstruction plate was removed intraorally to facilitate prosthetic rehabilitation. The ramal–condylar segment was left due to new bone growth around it (e)
Fig. 2
Fig. 2
a, b Clinical and radiographic picture (axial section) of the infant with MNTI. c Clinical picture of the child at the end of 2 years. d Extra-oral radiograph showing consolidated bone at the end of 1 year
See this image and copyright information in PMC

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