Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb;11(1):75-79.

The frequency of Epstein-Barr virus among hemodialysis patients, Ahvaz, Iran

Rahil Nahid Samiei  1 , Shahab Mahmoudvand  1 , Somayeh Shokri  1 , Manoochehr Makvandi  1   2 , Heshmatollah Shahbazian  3 , Roya Pirmoradi  1 , Shokouh Shayanpur  4 , Kimia Makvandi  5 , Sepideh Nowrozi  5
Affiliations

The frequency of Epstein-Barr virus among hemodialysis patients, Ahvaz, Iran

Rahil Nahid Samiei et al. Iran J Microbiol. 2019 Feb.

Abstract

Background and objectives: Epstein-Barr virus (EBV) has infected more than 90% of adults worldwide. EBV infection is asymptomatic in healthy individuals and is controlled by a robust immune response while in individuals with weakened immunesystems including Hemodialysis (HD) patients and transplant recipients leads to serious illnesses. This study was aimed to investigate the frequency of EBV among the HD patients.

Materials and methods: The cross-sectional study was carried out on 84 HD patients. These sera were checked for anti-EBV (VCA) IgG Ab assessment using enzyme-linked immunosorbent assay (ELISA). The DNA was extracted from the sera samples and tested for EBV DNA using nested PCR.

Results: 52/84 (61.9%) of HD were males and 32/84 (38.1%) were females. The average age of participants was varying from 18 to 85 years while the mean age was 52 ± 1.57 SD years. 81 of 84 (96.42%); including 49/52 (94.23%) male and 32/32 (100%) female, were positive for anti-EBV (VCA) IgG antibody while 3 (3.58%) were negative. No significant differences were observed between the subjects regarding gender (P=0.28). EBV DNA was detected in 7 (8.33%) individuals, including 6 (11.53%) and 1 (3.12%) in male and female, respectively (P=0.24).

Conclusion: Our study results showed that high prevalence of anti-EBV (VCA) IgG antibody (96.42%) were observed among the HD patients. Although the status of EBV latency was not performed, but it seems many of these patients are at risk of EBV-reactivation during the organ transplantation. As a result, it is recommended that the detection of EBNA-1 gene as a marker of EBV latency should be implemented for all HD patients to prevent EBV reactivation during organ transplantation.

Keywords: Enzyme-linked immunosorbent assay; Epstein-Barr virus; Hemodialysis patients.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Chabay P, Preciado MV. Epidemiology of Epstein-Barr virus-associated pediatric lymphomas from Argentina. Bol Med Hosp Infant Mex 2016;73:47–54. - PubMed
    1. Maeda E, Akahane M, Kiryu S, Kato N, Yoshikawa T, Hayashi N, et al. Spectrum of Epstein-Barr virus-related diseases: a pictorial review. Jpn J Radiol 2009;27:4–19. - PubMed
    1. Pagano JS. Is Epstein-Barr virus transmitted sexually? JID 2007;195:469–470. - PubMed
    1. Sitki-Green D, Covington M, Raab-Traub N. Compartmentalization and transmission of multiple epstein-barr virus strains in asymptomatic carriers. J Virol 2003;77:1840–1847. - PMC - PubMed
    1. Abecassis M, Bartlett ST, Collins AJ, Davis CL, Delmonico FL, Friedewald JJ, et al. Kidney transplantation as primary therapy for end-stage renal disease: a national kidney foundation/kidney disease outcomes quality initiative (NKF/KDOQI™) conference. Clin J Am Soc Nephrol 2008;3:471–480. - PMC - PubMed

LinkOut - more resources