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. 2019 Feb 19;7(4):836-838.
doi: 10.1002/ccr3.2029. eCollection 2019 Apr.

Verrucous carcinoma arising in a long standing Buschke-Löwenstein tumor

Ahmed G Elsayed  1 , Saidat T Sola-Rufai  1 , Doreen Griswold  1 , Toni Pacioles  1
Affiliations

Verrucous carcinoma arising in a long standing Buschke-Löwenstein tumor

Ahmed G Elsayed et al. Clin Case Rep. .

Abstract

Giant condyloma acuminatum is a rare variant of genital warts also known as Buschke-Löwenstein tumor. It is characterized by a slow progression of exophytic, ulcerative, and cauliflower-shaped tumor with benign histological features. Verrucous carcinoma however is a rare variant of well-differentiated squamous cell carcinoma with limited metastatic potential.

Keywords: Buschke‐Löwenstein tumor; giant condyloma acuminatum; squamous cell cancer; verrucous carcinoma.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Hematoxylin and eosin stain at 4x power. Cauliflower‐shaped lesion with no invasion to basement membrane consistent with.Buschke‐Löwenstein tumor
Figure 2
Figure 2
Gross appearance of Verrucous carcinoma status postsurgical drainage of perirectal abscess
Figure 3
Figure 3
Gross appearance of Verrucous carcinoma
Figure 4
Figure 4
Hematoxylin and eosin stain at 40x power showing well‐differentiated squamous cell carcinoma with underlying chronically inflamed stroma and foci where the basement membrane cannot be clearly visualized, concerning for superficial invasion
See this image and copyright information in PMC

References

    1. Buschke A, Loewenstein L. Über Carcinomähnliche Condylomata Acuminata des Penis. Klin Wochenschr. 1925;4(36);1726–1728.
    1. Knoblich R, Failing JF. Giant condyloma acuminatum (Buschke‐Löwenstein tumor) of the rectum. Am J Clin Pathol. 1967;48(4):389–395. - PubMed

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