Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Mar 22;6(1):e000897.
doi: 10.1136/openhrt-2018-000897. eCollection 2019.

Does elevated bilirubin aid weight control by preventing development of hypothalamic leptin resistance?

James J DiNicolantonio  1 , Mark McCarty  2 , James OKeefe  1
Affiliations
Editorial

Does elevated bilirubin aid weight control by preventing development of hypothalamic leptin resistance?

James J DiNicolantonio et al. Open Heart. .
No abstract available

Keywords: bilirubin; leptin; obesity; phycocyanobilin; spirulina.

PubMed Disclaimer

Conflict of interest statement

Competing interests: JJD is the author of The Salt Fix, Superfuel and The Longevity Solution. MM is an owner of a nutraceutical company and coinventor and co-owner of a US patent covering nutraceutical uses of phycocyanobilin oligopeptides derived from cyanobacteria such as spirulina. JO is an owner of a nutraceutical company.

References

    1. Kadakol A, Ghosh SS, Sappal BS, et al. . Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and gilbert syndromes: correlation of genotype to phenotype. Hum Mutat 2000;16:297–306. 10.1002/1098-1004(200010)16:4<297::AID-HUMU2>3.0.CO;2-Z - DOI - PubMed
    1. McCarty MF. Serum bilirubin may serve as a marker for increased heme oxygenase activity and inducibility in tissues – a rationale for the versatile health protection associated with elevated plasma bilirubin. Med Hypotheses 2013;81:607–10. 10.1016/j.mehy.2013.07.013 - DOI - PubMed
    1. Wallner M, Bulmer AC, Mölzer C, et al. . Haem catabolism: a novel modulator of inflammation in Gilbert's syndrome. Eur J Clin Invest 2013;43:912–9. 10.1111/eci.12120 - DOI - PubMed
    1. Seyed Khoei N, Grindel A, Wallner M, et al. . Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: implications for improved metabolic health. Atherosclerosis 2018;269:306–11. 10.1016/j.atherosclerosis.2017.12.021 - DOI - PubMed
    1. Liu J, Dong H, Zhang Y, et al. . Bilirubin increases insulin sensitivity by regulating cholesterol metabolism, adipokines and PPARγ levels. Sci Rep 2015;5 10.1038/srep09886 - DOI - PMC - PubMed

Publication types

LinkOut - more resources