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. 2019 Feb 7;3(Suppl 1):e000462.
doi: 10.1136/esmoopen-2018-000462. eCollection 2018.

Targeted therapy in cervical cancer

Chakor Vora  1 , Sudeep Gupta  2
Affiliations

Targeted therapy in cervical cancer

Chakor Vora et al. ESMO Open. .

Abstract

Cervical cancer continues to be a common cancer in women worldwide, especially in less developed regions where advanced stage presentations are common. Addition of bevacizumab to cytotoxic chemotherapy has been the only notable recent advance in the treatment of recurrent and metastatic cervical cancer. Outcomes in patients with locally advanced disease have also plateaued after meaningful gains were achieved with concomitant chemoradiation treatment. Recently, progress has been made in understanding the molecular aberrations in cervical cancer and new therapeutic modalities are emerging, including immune checkpoint inhibitors, therapeutic vaccines, antibody-drug conjugates, and others. In this review we will discuss the data and potential utility of these approaches.

Keywords: Cervical cancer; targeted therapy.

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Conflict of interest statement

Competing interests: SG has the following disclosures: Institutional financial interests for conducted research: Roche, Sanofi, Johnson & Johnson, Amgen, Celltrion, Oncosten, Novartis, Intas, Eisai, Biocon. Non-remunerated activities—Advisory board: Roche, Sanofi, Dr. Reddy’s Laboratories, Biocon, Pfizer, Oncosten, Core Diagnostics. Leadership roles: Vice-President of the Indian Society of Medical and Paediatric Oncology. General Secretary of a non-governmental organisation ‘Women’s Cancer Institute—Tata Memorial Hospital’.

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