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. 1986 Aug 1;237(3):931-4.
doi: 10.1042/bj2370931.

Accumulation of N1-acetylspermidine in heart and spleen of isoprenaline-treated rats

C Stefanelli, D Carati, C Rossoni, F Flamigni, C M Caldarera

Accumulation of N1-acetylspermidine in heart and spleen of isoprenaline-treated rats

C Stefanelli et al. Biochem J. .

Abstract

N1-Acetylspermidine is not detectable in rat heart, but its content greatly increases after a single injection of isoprenaline (10 mg/kg), reaching a concentration of about 10 nmol/g of tissue 4 h after the treatment. Part of the accumulated N1-acetylspermidine was split to putrescine. Isoprenaline also caused an increase of N1-acetylspermidine in the spleen, where its concentration increased 3.5-fold 6 h after the catecholamine. The accumulation of N1-acetylspermidine was dependent on the dose of isoprenaline in both the heart and the spleen, and was strongly inhibited by beta-antagonists and inhibitors of protein synthesis.

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