Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2019 Jun;7(6):e643.
doi: 10.1002/mgg3.643. Epub 2019 Apr 17.

Associations of intercellular adhesion molecule-1 rs5498 polymorphism with ischemic stroke: A meta-analysis

Hua Gao  1 , Xinhua Zhang  2
Affiliations
Meta-Analysis

Associations of intercellular adhesion molecule-1 rs5498 polymorphism with ischemic stroke: A meta-analysis

Hua Gao et al. Mol Genet Genomic Med. 2019 Jun.

Abstract

Background: Recently, associations between intercellular adhesion molecule-1 (ICAM-1) rs5498 polymorphism and ischemic stroke (IS) were investigated by several pilot studies, but with inconsistent results. In this study, a meta-analysis was performed to better assess the relationship between ICAM-1rs5498 polymorphism and IS.

Methods: PubMed, Medline, Embase, and CNKI were searched for eligible studies. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate associations between ICAM-1 rs5498 polymorphism and IS.

Results: Totally 16 studies with 2,596 cases and 11,800 controls were analyzed. A significant association with IS was observed for rs5498 polymorphism in GG versus AA + AG (recessive model, p = 0.009, OR = 1.62, 95% CI 1.13-2.32, I2 = 76%) in overall population. Further subgroup analyses showed that rs5498 polymorphism was significantly associated with IS in Caucasians in AA versus AG + GG (dominant model, p = 0.03, OR = 0.52, 95% CI 0.29-0.95, I2 = 72%), GG versus AA + AG (recessive model, p < 0.0001, OR = 2.98, 95% CI 2.05-4.31, I2 = 19%), and A versus G (allele model, p = 0.005, OR = 0.50, 95% CI 0.31-0.81, I2 = 81%). However, no any positive findings were detected for Asians.

Conclusions: Our findings indicated that rs5498 polymorphism was significantly associated with individual susceptibility to IS in Caucasians, but not in Asians.

Keywords: intercellular adhesion molecule-1 (ICAM-1); ischemic stroke (IS); meta-analysis; polymorphisms.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of study selection for the present study
See this image and copyright information in PMC

References

    1. Anrather, J. , & Iadecola, C. (2016). Inflammation and Stroke: An Overview. Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics, 13, 661–670. 10.1007/s13311-016-0483-x - DOI - PMC - PubMed
    1. Chauhan, G. , & Debette, S. (2016). Genetic risk factors for ischemic and hemorrhagic stroke. Current Cardiology Reports, 18, 124 10.1007/s11886-016-0804-z - DOI - PMC - PubMed
    1. Flex, A. , Gaetani, E. , Papaleo, P. , Straface, G. , Proia, A. S. , Pecorini, G. , … Pola, R. (2004). Proinflammatory genetic profiles in subjects with history of ischemic stroke. Stroke, 35, 2270–2275. 10.1161/01.str.0000140740.19421.fe - DOI - PubMed
    1. Global Burden of Disease Study 2013 Collaborators . (2015). Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet, 386, 743–800. 10.1016/S0140-6736(15)60692-4 - DOI - PMC - PubMed
    1. He, Q. , Lin, X. , Wang, F. , Xu, J. , Ren, Z. , Chen, W. , & Xing, X. (2014). Associations of a polymorphism in the intercellular adhesion molecule‐1 (ICAM1) gene and ICAM1 serum levels with migraine in a Chinese Han population. Journal of the Neurological Sciences, 345, 148–153. 10.1016/j.jns.2014.07.030 - DOI - PubMed

Publication types

Substances