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Case Reports
. 2019 Apr;74(4):179-184.

[Extended optic neuropathy with myelin oligodendrocyte glycoprotein antibodies]

[Article in French]
F Gillard  1 , C Andris  2 , E Lommers  3
Affiliations
  • PMID: 30997966
Free article
Case Reports

[Extended optic neuropathy with myelin oligodendrocyte glycoprotein antibodies]

[Article in French]
F Gillard et al. Rev Med Liege. 2019 Apr.
Free article

Abstract
in English, French

The discovery of autoantibodies targeting aquaporin-4 (AQP4) of astrocytes has improved the understanding and management of Neuromyelitis Optica Syndrome Disorders (NMO-SD), previously considered as a variant of multiple sclerosis. Later, the detection of MOG IgG1 antibodies, directed against an oligodendrocyte myelin glycoprotein, made it possible to distinguish pathologies with different clinical and prognostic particularities, then helping the clinician in his diagnostic and therapeutic approach. This clinical case aims to feature the clinical differences, prognosis and therapeutic solutions of these pathologies.

La découverte d’auto-anticorps ciblant l’aquaporine-4 (AQP4) des astrocytes a permis d’avancer dans la compréhension et la prise en charge du spectre des maladies de la neuromyélite optique (NMO-SD), antérieurement considérée comme une variante proche de la sclérose en plaques. Plus tard, la mise en évidence des anticorps MOG IgG1, dirigés contre une protéine de la myéline oligodendrocytaire, a permis de distinguer des pathologies avec des particularités cliniques et pronostiques différentes, pouvant aider le clinicien dans sa démarche diagnostique et thérapeutique. Ce cas clinique permet de détailler les différences cliniques et pronostiques ainsi que les solutions thérapeutiques de ces pathologies.

Keywords: Anti; Optic neuromyelitis; Optic neuropathy; Anti; aquaporin 4 antibody; myelin oligodendrocyte glycoprotein antibody.

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