Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jun;109(6):854-858.
doi: 10.2105/AJPH.2019.305016. Epub 2019 Apr 18.

Does Despair Really Kill? A Roadmap for an Evidence-Based Answer

Affiliations

Does Despair Really Kill? A Roadmap for an Evidence-Based Answer

Lilly Shanahan et al. Am J Public Health. 2019 Jun.

Abstract

Two seemingly associated demographic trends have generated considerable interest: income stagnation and rising premature mortality from suicides, drug poisoning, and alcoholic liver disease among US non-Hispanic Whites with low education. Economists interpret these population-level trends to indicate that despair induced by financial stressors is a shared pathway to these causes of death. Although we now have the catchy term "deaths of despair," we have yet to study its central empirical claim: that conceptually defined and empirically assessed "despair" is indeed a common pathway to several causes of death. At the level of the person, despair consists of cognitive, emotional, behavioral, and biological domains. Despair can also permeate social relationships, networks, institutions, and communities. Extant longitudinal data sets feature repeated measures of despair-before, during, and after the Great Recession-offering resources to test the role that despair induced by economic decline plays in premature morbidity and mortality. Such tests must also focus on protective factors that could shield individuals. Deaths of despair is more than a phrase; it constitutes a hypothesis that deserves conceptual mapping and empirical study with longitudinal, multilevel data.

PubMed Disclaimer

Figures

FIGURE 1—
FIGURE 1—
Hypothesized Developmental Progression From Economic Stagnation to Deaths of Despair

References

    1. Case A, Deaton A. Rising morbidity and mortality in midlife among White non-Hispanic Americans in the 21st century. Proc Natl Acad Sci U S A. 2015;112(49):15078–15083. - PMC - PubMed
    1. Case A, Deaton A. Mortality and morbidity in the 21st century. Brookings Pap Econ Act. 2017;2017(1):397–476. - PMC - PubMed
    1. Meit M, Hefferman M, Tanenbaum E, Hoffmann T. Final Report: Appalachian Diseases of Despair. Bethesda, MD: Walsh Center for Rural Health Analysis, NORC at the University of Chicago; 2017.
    1. Diez Roux AV. Despair as a cause of death: more complex than it first appears. Am J Public Health. 2017;107(10):1566–1567. - PMC - PubMed
    1. Stein EM, Gennuso KP, Ugboaja DC, Remington PL. The epidemic of despair among White Americans: trends in the leading causes of premature death, 1999-2015. Am J Public Health. 2017;107(10):1541–1547. - PMC - PubMed

Publication types