Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Apr 18;10(1):124.
doi: 10.1186/s13287-019-1222-0.

Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers

Yizuo Song  1 , Min Lin  1 , Yi Liu  1 , Zhi-Wei Wang  2   3 , Xueqiong Zhu  4
Affiliations
Review

Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers

Yizuo Song et al. Stem Cell Res Ther. .

Abstract

Emerging evidence shows that epithelial-mesenchymal transition (EMT) plays a crucial role in tumor invasion, metastasis, cancer stem cells, and drug resistance. Data obtained thus far have revealed that F-box proteins are critically involved in the regulation of the EMT process and stem cell differentiation in human cancers. In this review, we will briefly describe the role of EMT and stem cells in cell metastasis and drug resistance. We will also highlight how numerous F-box proteins govern the EMT process and stem cell survival by controlling their downstream targets. Additionally, we will discuss whether F-box proteins involved in drug resistance are associated with EMT and cancer stem cells. Targeting these F-box proteins might be a potential therapeutic strategy to reverse EMT and inhibit cancer stem cells and thus overcome drug resistance in human cancers.

Keywords: Cancer; Drug resistance; EMT; F-box protein; Metastasis; Stem cells.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Not applicable

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Illustration of how F-box proteins govern EMT-inducing transcription factors. F-box proteins regulate EMT through proteolysis of EMT-inducing factors. FBXL, F-box and leucine-rich repeat protein; FBXW, F-box and WD-40 domain protein; FBXO, F-box only protein
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Thiery JP, Acloque H, Huang RY, et al. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139:871–890. doi: 10.1016/j.cell.2009.11.007. - DOI - PubMed
    1. Gonzalez DM, Medici D. Signaling mechanisms of the epithelial-mesenchymal transition. Science Signaling. 2014;7:re8. doi: 10.1126/scisignal.2005189. - DOI - PMC - PubMed
    1. Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 2006;7:131–142. doi: 10.1038/nrm1835. - DOI - PubMed
    1. Baulida J, Garcia de Herreros A. Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy. Biochim Biophys Acta. 1856;2015:55–61. - PubMed
    1. Barkeer S, Chugh S, Batra SK, et al. Glycosylation of cancer stem cells: function in stemness, tumorigenesis, and metastasis. Neoplasia. 2018;20:813–825. doi: 10.1016/j.neo.2018.06.001. - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources