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. 1986 Dec;39(6):386-9.
doi: 10.1007/BF02555176.

Inhibition of bone cell metabolism increases strontium-85 uptake

I D McCarthy, S P Hughes

Inhibition of bone cell metabolism increases strontium-85 uptake

I D McCarthy et al. Calcif Tissue Int. 1986 Dec.

Abstract

Experiments have been performed on the canine tibia to investigate whether perturbation of the energy metabolism of bone cells can influence the short-term exchange of bone mineral. Simultaneous injection of three radioactive tracers, 125I-albumin, 85Sr, and 86Rb, into the tibial nutrient artery was followed immediately by measurement of the concentration of these tracers in the venous outflow from the bone for a period of 5 minutes. This procedure was performed before and after the injection of potassium cyanide into the bone. From the measured concentrations, extraction ratios for 85Sr and 86Rb with respect to 125I-albumin were calculated. It was found that net extraction after 5 minutes of 85Sr was significantly increased. This result indicates that efflux of ions from exchangeable mineral is dependent to a significant extent on the metabolic activity of bone cells.

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References

    1. J Orthop Res. 1984;2(1):2-7 - PubMed
    1. Calcif Tissue Int. 1982 Mar;34(2):117-20 - PubMed
    1. Calcif Tissue Int. 1983 Jul;35(4-5):508-11 - PubMed
    1. J Appl Physiol. 1974 Feb;36(2):221-5 - PubMed
    1. Calcif Tissue Res. 1976 Apr 20;(2):151-8 - PubMed

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