When genome editing goes off-target
- PMID: 31000651
- DOI: 10.1126/science.aax1827
When genome editing goes off-target
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Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.Science. 2019 Apr 19;364(6437):289-292. doi: 10.1126/science.aav9973. Epub 2019 Feb 28. Science. 2019. PMID: 30819928 Free PMC article.
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Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice.Science. 2019 Apr 19;364(6437):292-295. doi: 10.1126/science.aaw7166. Epub 2019 Feb 28. Science. 2019. PMID: 30819931
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Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.Science. 2019 Apr 19;364(6437):286-289. doi: 10.1126/science.aav9023. Epub 2019 Apr 18. Science. 2019. PMID: 31000663 Free PMC article.
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