Functional degradation ignites the inflammasome

Affiliations

Comment

Alexandra Flemming. Nat Rev Immunol. 2019 Jun.

. 2019 Jun;19(6):349.

doi: 10.1038/s41577-019-0169-9.

No abstract available

Comment on

N-terminal degradation activates the NLRP1B inflammasome.
Chui AJ, Okondo MC, Rao SD, Gai K, Griswold AR, Johnson DC, Ball DP, Taabazuing CY, Orth EL, Vittimberga BA, Bachovchin DA. Chui AJ, et al. Science. 2019 Apr 5;364(6435):82-85. doi: 10.1126/science.aau1208. Epub 2019 Mar 14. Science. 2019. PMID: 30872531 Free PMC article.
Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes.
Sandstrom A, Mitchell PS, Goers L, Mu EW, Lesser CF, Vance RE. Sandstrom A, et al. Science. 2019 Apr 5;364(6435):eaau1330. doi: 10.1126/science.aau1330. Epub 2019 Mar 14. Science. 2019. PMID: 30872533 Free PMC article.

1. Sandstrom, A. et al. Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes. Science 364, eaau1330 (2019) - DOI
1. Chui, A. J. et al. N-terminal degradation activates the NLRP1B inflammasome. Science 364, 82–85 (2019) - DOI