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Comment
. 2019 Jul;29(7):512-513.
doi: 10.1038/s41422-019-0167-2.

RNA binding to p62 impacts selective autophagy

Mohit Misra  1   2 , Ivan Dikic  3   4
Affiliations
Comment

RNA binding to p62 impacts selective autophagy

Mohit Misra et al. Cell Res. 2019 Jul.
No abstract available

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Figures

Fig. 1
Fig. 1
RNA binding negatively regulates p62-mediated autophagy. a p62 contains an N-terminal PB1 domain that is responsible for its oligomeric character followed by a zinc finger domain. C-terminal LIR motif and UBA domain are responsible for binding to Atg8 family members and ubiquitin (Ub) chains, respectively. Vault RNA1-1, a small non-coding RNA, blocks p62 oligomerization via interaction with the PB1 and ZZ domains. This results in the inhibition of p62 activity as autophagy receptor. b Starved cells show low levels of vtRNA1-1, which enables p62 multimerization. Thus, Ub-dependent selective autophagy is favored under starvation in a p62-mediated manner. The members of ATG8 family (LC3s/GABARAPs) are colored in purple
See this image and copyright information in PMC

Comment on

  • The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy.
    Horos R, Büscher M, Kleinendorst R, Alleaume AM, Tarafder AK, Schwarzl T, Dziuba D, Tischer C, Zielonka EM, Adak A, Castello A, Huber W, Sachse C, Hentze MW. Horos R, et al. Cell. 2019 Feb 21;176(5):1054-1067.e12. doi: 10.1016/j.cell.2019.01.030. Epub 2019 Feb 14. Cell. 2019. PMID: 30773316

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