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Review
. 2019 Jan-Mar;10(1):6-13.
doi: 10.4103/jmh.JMH_7_19.

Menopausal Hot Flashes: A Concise Review

Ramandeep Bansal  1 , Neelam Aggarwal  1
Affiliations
Review

Menopausal Hot Flashes: A Concise Review

Ramandeep Bansal et al. J Midlife Health. 2019 Jan-Mar.

Abstract

Hot flashes (HFs), defined as transient sensations of heat, sweating, flushing, anxiety, and chills lasting for 1-5 min, constitute one of the most common symptoms of menopause among women though only a few seek treatment for these. The basis of HFs lies in abnormal hypothalamic thermoregulatory control resulting in abnormal vasodilatory response to minor elevations of core body temperature. Recent data suggest an important role for calcitonin gene-related peptide, hypothalamic kisspeptin, neurokinin B and dynorphin signal system, serotonin, norepinephrine in causation of HFs in addition to estrogen deficiency which plays a cardinal role. The mainstay of treatment includes hormonal replacement therapy, selective serotonin, and norepinephrine reuptake inhibitors in addition to lifestyle modification. In this review, we address common issues related to menopause HFs and suggest a stepwise approach to their management.

Keywords: Hormone replacement therapy; hot flashes; menopause.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Step-wise approach to management of menopausal hot flashes
See this image and copyright information in PMC

References

    1. de Zambotti M, Colrain IM, Javitz HS, Baker FC. Magnitude of the impact of hot flashes on sleep in perimenopausal women. Fertil Steril. 2014;102:1708–150. - PMC - PubMed
    1. Freeman EW, Sammel MD, Sanders RJ. Risk of long-term hot flashes after natural menopause: Evidence from the Penn Ovarian Aging Study cohort. Menopause. 2014;21:924–32. - PMC - PubMed
    1. ACOG practice bulletin no. 141: Management of menopausal symptoms. Obstet Gynecol. 2014;123:202–16. - PubMed
    1. Reed SD, Lampe JW, Qu C, Copeland WK, Gundersen G, Fuller S, et al. Premenopausal vasomotor symptoms in an ethnically diverse population. Menopause. 2014;21:153–8. - PubMed
    1. Col NF, Guthrie JR, Politi M, Dennerstein L. Duration of vasomotor symptoms in middle-aged women: A longitudinal study. Menopause. 2009;16:453–7. - PubMed

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