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Review
. 2019 Apr 2:10:715.
doi: 10.3389/fpsyg.2019.00715. eCollection 2019.

Pain, Parental Involvement, and Oxytocin in the Neonatal Intensive Care Unit

Manuela Filippa  1   2   3 , Pierrick Poisbeau  4 , Jérôme Mairesse  5   6 , Maria Grazia Monaci  3 , Olivier Baud  5   6   7 , Petra Hüppi  1   6 , Didier Grandjean  2 , Pierre Kuhn  4   7
Affiliations
Review

Pain, Parental Involvement, and Oxytocin in the Neonatal Intensive Care Unit

Manuela Filippa et al. Front Psychol. .

Abstract

Preterm infants (PTI) typically experience many painful and stressful procedures or events during their first weeks of life in a neonatal intensive care unit, and these can profoundly impact subsequent brain development and function. Several protective interventions during this sensitive period stimulate the oxytocin system, reduce pain and stress, and improve brain development. This review provides an overview of the environmental risk factors experienced by PTI during hospitalization, with a focus on the effects of pain, and early maternal separation. We also describe the long-term adverse effects of the simultaneous experiences of pain and maternal separation, and the potential beneficial effects of maternal vocalizations, parental contact, and several related processes, which appear to be mediated by the oxytocin system.

Keywords: early contact; early separation; pain; parents; prematurity.

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Figures

FIGURE 1
FIGURE 1
Possible effect of early contact on the different phases of a preterm infant’s experience of pain in the NICU and role of the OXT system.
See this image and copyright information in PMC

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References

    1. Adams-Chapman I., Heyne R. J., DeMauro S. B., Duncan A. F., Hintz S. R., Pappas A., et al. (2018). Neurodevelopmental impairment among extremely preterm infants in the neonatal research network. Pediatrics 141:e20173091. 10.1542/peds.2017-3091 - DOI - PMC - PubMed
    1. Alfvén G., Torre B., Uvnäs-Moberg K. (1994). Depressed concentrations of oxytocin and cortisol in children with recurrent abdominal pain of non-organic origin. Acta Paediatr. 83 1076–1080. 10.1111/j.1651-2227.1994.tb12989.x - DOI - PubMed
    1. Allegaert K., van den Anker J. N. (2016). Neonatal pain management: still in search for the Holy Grail. Int. J. Clin. Pharmacol. Ther. 54 514–523. 10.5414/CP202561 - DOI - PMC - PubMed
    1. Als H., Duffy F. H., McAnulty G. B., Rivkin M. J., Vajapeyam S., Mulkern R. V., et al. (2004). Early experience alters brain function and structure. Pediatrics 113 846–857. 10.1542/peds.113.4.846 - DOI - PubMed
    1. Amini-Khoei H., Mohammadi-Asl A., Amiri S., Hosseini M. J., Momeny M., Hassanipour M., et al. (2017). Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation. Prog. Neuro Psychopharmacol. Biol. Psychiatry 76 169–178. 10.1016/j.pnpbp.2017.02.022 - DOI - PubMed

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