Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Apr 15;2019(4):omz004.
doi: 10.1093/omcr/omz004. eCollection 2019 Apr.

Bullous dermatosis suspected in an 8-month-old child in Guinea-Bissau

Beatriz Valle Del Barrio  1 , Danila Luraschi  1 , Robert Micheletti  2 , Laurent Hiffler  3 , Ana Paula Arias  4
Affiliations
Case Reports

Bullous dermatosis suspected in an 8-month-old child in Guinea-Bissau

Beatriz Valle Del Barrio et al. Oxf Med Case Reports. .

Erratum in

Abstract

An 8-month-old child was admitted to a paediatric intensive care unit in Guinea-Bissau with severe blistering dermatosis. He was treated with broad spectrum antibiotics and dressings, without improvement. After 2 weeks, linear IgA bullous dermatosis was suspected. Owing to lack of dapsone, the child was treated with prednisolone and improved. To avoid corticosteroids side effects, 2 months after starting prednisolone we switched to colchicine, but the boy's condition worsened for reasons of poor adherence, requiring intravenous corticosteroids and antibiotics. After complete resolution of the skin lesions, we continued with colchicine monotherapy, then changed to dapsone after 3 months. The child did not show any further signs of dermatosis, but his follow-up ended abruptly, because he did not return to the hospital. IgA bullous dermatosis is a challenging diagnosis in settings where pathological studies cannot be conducted. Multidisciplinary treatment is required and colchicine is a good option if dapsone is not available.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:
Timeline.
Figure 2:
Figure 2:
At admission. *Note: ‘crown of jewels’ blistering pattern.
Figure 3:
Figure 3:
After three weeks’ treatment with prednisolone.
Figure 4:
Figure 4:
After 5 weeks under colchicine.
Figure 5:
Figure 5:
After 2 weeks under dapsone (usual first-line treatment, but was not available in this setting).
See this image and copyright information in PMC

References

    1. Wojnarowska F, Marsden RA, Bhogal B, Black MM. Chronic bullous disease of childhood, childhood cicatricial pemphigoid, and linear IgA disease of adults. J Am Acad Dermatol 1988;19:792–805. - PubMed
    1. Kharfi M, Khaled A, Ridha MR. Linear IgA dermatosis in Tunisian children: 31 cases. Indian J Dermatol 2011;56:153–9. - PMC - PubMed
    1. Kharfi M, Khaled A, Karaa A, Zaraa I, Fazaa B, Kamou MR. Linear IgA bullous dermatosis: the more frequent bullous dermatosis of children. Dermatol Online J 2010;16:2. - PubMed
    1. Venning VA Linear IgA disease: clinical presentation, diagnosis, and pathogenesis. Dermatol Clin 2011;29:453–8. - PubMed
    1. Fortuna G, Marinkovich MP. Linear immunoglobulin A bullous dermatosis. Clin Dermatol 2012;30:38–50. 10.1016/j.clindermatol.2011.03.008. - DOI - PubMed

Publication types