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. 2019 Apr 3:6:19.
doi: 10.3389/fmolb.2019.00019. eCollection 2019.

Applying Machine Learning of Erythrocytes Dynamic Antigens Store in Medicine

Mahmoud Rafea  1 , Passant Elkafrawy  2 , Mohammed M Nasef  2 , Rasha Elnemr  1 , Amani Tariq Jamal  3
Affiliations

Applying Machine Learning of Erythrocytes Dynamic Antigens Store in Medicine

Mahmoud Rafea et al. Front Mol Biosci. .

Abstract

Erythrocytes Dynamic Antigens Store (EDAS) is a new discovery. EDAS consists of self-antigens and foreign (non-self) antigens. In patients with infectious diseases or malignancies, antigens of infection microorganism or malignant tumor exist in EDAS. Storing EDAS of normal individuals and patients in a database has, at least, two benefits. First, EDAS can be mined to determine biomarkers representing diseases which can enable researchers to develop a new line of laboratory diagnostic tests and vaccines. Second, EDAS can be queried, directly, to reach a precise diagnosis without the need to do many laboratory tests. The target is to find the minimum set of proteins that can be used as biomarkers for a particular disease. A hypothetical EDAS is created. Hundred-thousand records are randomly generated. The mathematical model of hypothetical EDAS together with the proposed techniques for biomarker discovery and direct diagnosis are described. The different possibilities that may occur in reality are experimented. Biomarkers' proteins are identified for pathogens and malignancies, which can be used to diagnose conditions that are difficult to diagnose. The presented tool can be used in clinical laboratories to diagnose disease disorders.

Keywords: biomarkers; computer tools in clinics; disorders diagnosis; erythrocytes dynamic antigens store (EDAS); mass spectrometry; mathematical model.

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Figures

Figure 1
Figure 1
The central role of mass spectrometry in proteomics (Jain, 2010).
Figure 2
Figure 2
The relation between plasma antibodies and EDAS.
Figure 3
Figure 3
Workflow pipeline of the experiment.
Figure 4
Figure 4
Common-shared malignancy proteins.
Figure 5
Figure 5
Biomarkers found from EDAS.
See this image and copyright information in PMC

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References

    1. American Cancer Society (2017). Cancer Facts and Figures. Atlanta, GA: American Cancer Society.
    1. Barnes M. R., Gray I. C. (2003). Bioinformatics for Geneticists. Chichester, England: John Wiley & Sons Ltd.
    1. Borrebaeck C. A. (2017). Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer. Nat. Rev. Cancer 17, 199–204. 10.1038/nrc.2016.153 - DOI - PubMed
    1. Brennan D. J., O'Connor D. P., Rexhepaj E., Ponten F., Gallagher W. M. (2010). Antibody-based proteomics: fast-tracking molecular diagnostics in oncology. Nat. Rev. Cancer 10, 605–617. 10.1038/nrc2902 - DOI - PubMed
    1. Bryk A. H., Wisniewski J. R. (2017). Quantitative analysis of human red blood cell proteome. J. Proteome Res. 16, 2752–2761. 10.1021/acs.jproteome.7b00025 - DOI - PubMed

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