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Comment
. 2019 Apr 18;177(3):518-520.
doi: 10.1016/j.cell.2019.03.051.

Polygenic Risk Scores Expand to Obesity

Ali Torkamani  1 , Eric Topol  2
Affiliations
Free article
Comment

Polygenic Risk Scores Expand to Obesity

Ali Torkamani et al. Cell. .
Free article

Abstract

Obesity is one of the most serious health challenges of our time. In this issue of Cell, Khera and co-authors demonstrate the striking ability of genetics, in the form of a polygenic risk score, to identify those individuals at high risk for obesity. This genetic risk expresses itself early as childhood obesity, reinforcing the notion that early prevention is essential to combatting the obesity epidemic.

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  • Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.
    Khera AV, Chaffin M, Wade KH, Zahid S, Brancale J, Xia R, Distefano M, Senol-Cosar O, Haas ME, Bick A, Aragam KG, Lander ES, Smith GD, Mason-Suares H, Fornage M, Lebo M, Timpson NJ, Kaplan LM, Kathiresan S. Khera AV, et al. Cell. 2019 Apr 18;177(3):587-596.e9. doi: 10.1016/j.cell.2019.03.028. Cell. 2019. PMID: 31002795 Free PMC article.

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